Overview

1. Gout is a form of arthritis that causes sudden, severe attacks of pain, tenderness, redness, warmth, and swelling (inflammation) in some joints.

2. It often affects one joint at a time, but may affect a few or even many.

3. The large toe is most often affected, but gout can also affect other joints in the leg (knee, ankle, foot) and less often in the arms (hand, wrist, and elbow). The spine is rarely affected.

Cause

• Although diet and excessive drinking of alcohol can contribute to the development of gout, they are not the main cause of the disorder. 
• Gout results from abnormal deposits of sodium urate crystals around the joint cartilage and their later release into the joint fluid. 
• Urate crystals can also form in the kidney, causing kidney stones. 
• Sodium urate is formed from uric acid, a natural chemical in the body. 
• Uric acid comes from the natural breakdown of RNA and DNA (the genetic material in cells). Some foods contain large amounts of uric acid, especially red meats and internal organs (such as liver and kidneys), some shellfish, and anchovies. 
• Patients who eat more meat and fish (and less dairy) or drink more beer and liquor seem to be more prone to gout. 
• But changing these habits may only partially reduce the likelihood of stopping gout attacks once they have started.

How Frequent Are Gout Attacks? 

• Gout attacks can recur from time to time in the same or different joints. 
• The initial attack may last several days to two weeks unless it is treated. 
• Over time, gout attacks may occur more often, involve more joints, have more severe symptoms, and last longer. Repeated attacks can damage the joint. 
• Lumpy collections of uric acid called tophi can develop near joints, in the skin, or within bones. 
• Some people will only have a single attack. However, about 90 percent of patients who have one gout attack will have at least a second attack, although it may not occur for several years after the initial attack. Others may have attacks every few weeks. 

Who Is Affected By Gout? 

• Men (usually over age 40) and women after menopause
• People who are overweight
• People who frequently drink alcohol
• When gout affects women, it is usually after menopause, especially in women who are taking certain medicines. 
• Younger patients may be affected by gout if they have been taking certain medicines for long periods of time, frequently drink alcoholic beverages, or have certain genetic disorders.

Symptoms

• Sudden, intense joint pain, which often first occurs in the early morning hours
• Swollen, tender joint that’s warm to the touch
• Red or purple skin around the joint

Diagnosis

• Gout cannot be diagnosed simply from a blood test, since many people have elevated blood uric acid levels, but never develop gout. Rather, gout is diagnosed from the fluid withdrawn from an inflamed joint. 
• The fluid is observed under a microscope for sodium urate crystals. 
• Fluid is removed through a needle from the inflamed joint during a procedure called arthrocentesis. 
• Removing the fluid may reduce pressure within the joint and thereby reduce pain.
• A lack of crystals does not necessarily rule out a diagnosis of gout. Occasionally, crystals may not be observed the first time, but may be seen if additional fluid is removed at another time during a subsequent attack. 
• Since gout can cause chronic joint pain and involve other joints, it is extremely important that an accurate diagnosis be made. Then, your doctor can prescribe the appropriate specific treatment.

Treatment plan

• There is no cure for gout, but it can be treated and controlled. Symptoms are often dramatically improved within 24 hours after treatment has begun. 
• Attacks can be prevented with appropriate therapy to lower the blood uric acid level. 
• The goals of treatment are to: 

1. Relieve pain and inflammation
2. Prevent future gout attacks could lead to permanent joint damage

• The type of treatment prescribed will depend on several factors, including the person’s age, type of medicines he or she is taking, overall health, medica history, and severity of gout attacks. 
• Gout is mainly treated with medicine. 
• NSAIDs usually reduce inflammation and pain within hours. 
• Anti inflammatory drugs will reduce the pain and swelling of attacks. They are usually continued until the gout attack completely resolves.
• Corticosteroids may be prescribed for people who cannot take NSAIDs. Steroids also work by decreasing inflammation. Steroids can be injected into the affected joint or given as pills. 
• Colchicine is sometimes used in low doses for a long period of time to reduce the risk of recurrent attacks of gout
• If you have kidney disease, heart failure, diabetes, ulcer disease or other chronic conditions, the choice of therapy to treat the gout is affected. 
• Drugs that lower the level of uric acid in the blood. (Examples are allopurinol, probenecid and febuxostat). 
• These drugs are recommended for patients who have had multiple attacks of gout or kidney stones due to uric acid. 
• The goal of treatment is to reduce the uric acid level to less than 6 mg/dL. 
• The goal of lowering the blood uric acid is to slowly dissolve joint deposits of sodium urate. Lowering the uric acid will not treat an acute attack, but will over time prevent additional attacks from occurring. Sudden lowering of the uric acid level may cause an acute attack of gout. 
• To prevent acute attacks in people who are taking uric acid lowering drugs, colchicine, or an NSAID is temporarily prescribed. If an attack occurs while taking a medication to lower the uric acid, this medicine should NOT be stopped? stopping and starting the uric acid lowering medication may cause additional attacks. 
• Not all patients will develop side effects from gout medications. How often any side effect occurs varies from patient to patient. The occurrence of side
• effects depends on the dose, type of medication, concurrent illnesses, or other medicines the patient may be taking. 
• If any rash or itching develops while taking allopurinol, the medicine should be stopped immediately andyour physician notified.

Can Gout Be Treated Through Diet? 

• Dietary changes for most people do not play a major role in controlling their uric acid levels. 
• However, limiting certain foods, such as fructose containing corn syrup, red meat, beer that cause an increased production of uric acid and reducing alcohol intake are often helpful. Certain foods likes cherries, low fat diary products can decrease uric acid levels.